Many studies have linked brain volume abnormalities to a variety of mental health conditions, including major depressive disorder (MDD), bipolar disorder, and schizophrenia. But the author of an analysis published online April 4 in Archives of General Psychiatry concludes that the number of statistically significant results in the brain volume literature is «way too large to be true.»
«This pattern suggests strong biases in the literature,» writes John P. A. Ioannidis, MD, DSc, of Stanford University’s Prevention Research Center in California. «Selective outcome reporting and selective analyses reporting» are 2 possible explanations for the «excess significance bias» uncovered in the literature on brain volume abnormalities.
Reached for comment on the analysis, John D. Port, MD, PhD, associate professor of radiology and assistant professor of psychiatry at Mayo Clinic, Rochester, Minnesota, called Dr. Ioannidis’ article and analysis «pretty darn good and not surprising at all.» The excess of statistically significant results», Dr. Port said, «is a side effect of statistics and publication bias, in my opinion.»
Les mer: Scientific Literature on Brain Volume Abnormalities Overblown, Expert Says (Krever gratis registrering og innlogging på Medscape.com)
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